Using Lithium Safely
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چکیده
It has been over 60 years since Australian psychiatrist John Cade first described lithium’s therapeutic role in manic illness. Cade’s seminal 1949 article described the impact of lithium salts in resolving “psychotic excitement” in 10 manic patients. Since this discovery, lithium has become a gold standard treatment for bipolar disorder, with evidence supporting its role in acute mania, depression and prophylactic treatment. It is also efficacious as augmentation therapy in refractory unipolar depression. In addition, it has been noted to effect aggressiveness, reduce suicide rates in affective disorders and, more speculatively, has been considered as a possible therapeutic agent for treating chronic neurodegenerative diseases.
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